학술논문
Real-world evidence on the use of daratumumab, bortezomib and dexamethasone (DVd) in lenalidomide-refractory myeloma patients: subgroup analysis of the multicenter retrospective experience by "rete ematologica pugliese".
Document Type
Article
Author
Mele, Giuseppe; Di Renzo, Nicola; Cascavilla, Nicola; Carella, Angelo Michele; Guarini, Attilio; Mazza, Patrizio; Melillo, Lorella; Pavone, Vincenzo; Tarantini, Giuseppe; Curci, Paola; Falcone, Anna P.; Germano, Candida; Mele, Anna; Merchionne, Francesca; Palazzo, Giulia; Palumbo, Gaetano; Quinto, Angela Maria; Reddiconto, Giovanni; Rossini, Bernardo; Spina, Alessandro
Source
Subject
*DARATUMUMAB
*MULTIPLE myeloma
*BORTEZOMIB
*SUBGROUP analysis (Experimental design)
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Language
ISSN
1042-8194
Abstract
(a) Cohort of Multiple Myeloma patients treated with DVd (Daratumumab + Bortezomib + Dexamethasone): OS in the subgroup of "Lenalidomide-refractory patients" (70.6% of patients). The last treatment received before the DVd regimen was Carfilzomib-Lenalidomide-Dexamethasone (KRd) (39.6%), Lenalidomide-Dexamethasone (Rd) (39.6%), Elotuzumab-Lenalidomide-Dexamethasone (EloRd) (14.6%) and Ixazomib-Lenalidomide-Dexamethasone (IxaRd) (6.2%). (range 1-34) ht 1 Hgb: hemoglobin; LDH: lactate dehydrogenase; 2M: 2microglobulin; DVd: Daratumumab-Bortezomib-Dexamethasone; KRd: Carfilzomib-Lenalidomide-Dexamethasone; Rd: Lenalidomide-Dexamethasone; EloRd: Elotuzumab-Lenalidomide-Dexamethasone; IxaRd: Ixazomib-Lenalidomide-Dexamethasone. (b) Cohort of Multiple Myeloma patients treated with DVd (Daratumumab + Bortezomib + Dexamethasone): TTP in the subgroup of "Lenalidomide-refractory patients" (70.6% of patients). [Extracted from the article]