부산대학교 도서관

For "true" mtDNA editing, there are several generations of cytosine base editors which do not require the cleavage of one of the mtDNA variants [[7]]. Human mitochondria contain a double-stranded circular DNA (mtDNA) that encodes information about the core structures of the oxidative phosphorylation complexes as well as the elements of machinery for translation of mtDNA genes. It is also not clear how mutated mtDNA will be distributed in the embryonic tissues, and due to the low mtDNA replication at the preimplantation embryonic stage [[17]] and the possible mosaicism, analyses of the mtDNA in the trophectoderm biopsy samples might not represent the accurate picture of the mutated mtDNA load. The recent discovery (although extremely questionable - see [[21]]) of the frequent biparental inheritance of mtDNA [[22]] suggests that the mixes of mtDNA haplotypes are pretty common in our species, and thus, there is nothing risky in the "creation" of offspring with mixed mtDNA haplotypes. [Extracted from the article]