학술논문
A balanced Oct4 interactome is crucial for maintaining pluripotency.
Document Type
Article
Author
Source
Subject
*RIBOSOMAL DNA
*GENE targeting
*COMPUTATIONAL biology
*DEVELOPMENTAL biology
*PROTEOMICS
*GREEN fluorescent protein
*TETRAPLOIDY
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Language
ISSN
2375-2548
Abstract
The article discusses how a balanced Oct4 maintains pluripotency in vitro. It shows how Oct4 linker mutant embryonic stem cells (ESCs) resulted in impaired ESC self-renewal and early development of embryo from decreasing expression of self-renewal genes and increasing expression of differentiation genes. Also noted is the finding that how Oct4 exerted its function remains unclear.