학술논문
The First 1-Hydroxypropylidenebisphosphonic Acid with 1,8-Naphthyridinone Substituent: Synthesis and Structure.
Document Type
Article
Author
Source
Subject
*PHOSPHONIC acid derivatives
*NAPHTHYRIDINES
*CHEMICAL structure
*CHEMICAL precursors
*PROPIONIC acid derivatives
*METHYL formate
*CHEMICAL synthesis
*DIPHOSPHONATES
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Language
ISSN
1070-3632
Abstract
1-Hydroxy-3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propylidenebisphosphonic acid has been synthesized. The structure of the acid and its precursors synthesized for the first time, 3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propionic acid and the corresponding methyl ester, in the solid state and in the DMSO solution has been elucidated by means of vibrational (IR and Raman) and multinuclear (1H, 13C, and 31P) NMR spectroscopy. [ABSTRACT FROM AUTHOR]