학술논문
A Luminescent Sensor for Tyrosine Phosphorylation.
Document Type
Article
Author
Source
Subject
*TYROSINE
*PHOSPHORYLATION
*CHEMICAL reactions
*LUMINESCENCE
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*
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Language
ISSN
1523-7060
Abstract
We have developed a luminogenic probe for tyrosine phosphorylation based on a short peptide sequence containing an iminodiacetate moiety near the site of phosphorylation. In response to kinase activity, the probe provides a strong luminescence enhancement, resulting from the increased ability of the probe to bind and sensitize Tb3and Eu3ions upon phosphorylation. [ABSTRACT FROM AUTHOR]