학술논문
Analysis of linkage between lymphotoxin α haplotype and polymorphisms in 5′-flanking region of tumor necrosis factor α gene associated with efficacy of infliximab for Crohn's disease patients
Document Type
Article
Author
Source
Subject
*GENETIC polymorphisms
*POPULATION genetics
*IMMUNOGLOBULIN idiotypes
*CYTOKINES
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Language
ISSN
0027-5107
Abstract
Abstract: Tumor necrosis factor (TNF)α is increased in patients with Crohn''s disease (CD) and considered to play an important role in the inflammation. Infliximab (IFX) is used as a therapeutic agent for CD. Recently, it was reported that homozygosity for a lymphotoxin α (LTA) haplotype (LTA 1-1-1-1) may identify subgroups with a poor response to IFX. In the present study, we characterized the linkage of the LTA haplotype with SNPs in the 5′-flanking region of the TNFα gene. In subjects who had homozygosity for each LTA haplotype, 6 nucleotide variations, −857C>T, −522C>G, −357A>C, −261C>G, −159G>T and −96G>T, were found in the 5′-flanking region of the TNFα gene. As for linking with the allele, only −857T met the LTA haplotype 1-1-1-1. We concluded that the differences in therapeutic effects of IFX among patients with CD may be explained in part by the induction ability of TNFα via the −857C>T polymorphism. [Copyright &y& Elsevier]