학술논문
Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) and Growth Differentiation Factor-15 (GDF-15) Levels Are Significantly Associated with Endothelial Injury Indices in Adult Allogeneic Hematopoietic Cell Transplantation Recipients.
Document Type
Article
Author
Gavriilaki, Eleni; Bousiou, Zoi; Batsis, Ioannis; Vardi, Anna; Mallouri, Despina; Koravou, Evaggelia-Evdoxia; Konstantinidou, Georgia; Spyridis, Nikolaos; Karavalakis, Georgios; Noli, Foteini; Patriarcheas, Vasileios; Masmanidou, Marianna; Touloumenidou, Tasoula; Papalexandri, Apostolia; Poziopoulos, Christos; Yannaki, Evangelia; Sakellari, Ioanna; Politou, Marianna; Papassotiriou, Ioannis
Source
Subject
*PLASMINOGEN activators
*HEMATOPOIETIC stem cell transplantation
*HEMATOPOIETIC stem cells
*GRAFT versus host disease
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Language
ISSN
1661-6596
Abstract
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) and graft-versus-host disease (GvHD) represent life-threatening syndromes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In both conditions, endothelial dysfunction is a common denominator, and development of relevant biomarkers is of high importance for both diagnosis and prognosis. Despite the fact that soluble urokinase plasminogen activator receptor (suPAR) and growth differentiation factor-15 (GDF-15) have been determined as endothelial injury indices in various clinical settings, their role in HSCT-related complications remains unexplored. In this context, we used immunoenzymatic methods to measure suPAR and GDF-15 levels in HSCT-TMA, acute and/or chronic GVHD, control HSCT recipients, and apparently healthy individuals of similar age and gender. We found considerably greater SuPAR and GDF-15 levels in HSCT-TMA and GVHD patients compared to allo-HSCT and healthy patients. Both GDF-15 and suPAR concentrations were linked to EASIX at day 100 and last follow-up. SuPAR was associated with creatinine and platelets at day 100 and last follow-up, while GDF-15 was associated only with platelets, suggesting that laboratory values do not drive EASIX. SuPAR, but not GDF-15, was related to soluble C5b-9 levels, a sign of increased HSCT-TMA risk. Our study shows for the first time that suPAR and GDF-15 indicate endothelial damage in allo-HSCT recipients. Rigorous validation of these biomarkers in many cohorts may provide utility for their usefulness in identifying and stratifying allo-HSCT recipients with endothelial cell impairment. [ABSTRACT FROM AUTHOR]