학술논문
ANALYSIS IN SPONTANEOUSLY HYPERTENSIVE RATS.
Document Type
Article
Author
Source
Subject
*HYPERTENSION
*RATS
*PHYSIOLOGICAL effects of salt
*GENETICS
*ANIMAL models in research
SEX differences (Biology)
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*
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Language
ISSN
0305-1870
Abstract
1. Linkage analysis is performed between basal or salt- sensitive high blood pressure and several loci on chromosomes in F2 progenies obtained from crossing stroke-prone spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats. 2. Basal hypertensive genes are mapped to a region near the D1Mit2 locus on chromosome 1 and near the D3Mgh8 locus on chromosome 3 in the male and female F2 progenies. 3. Salt-sensitive hypertensive gene is mapped to a region near RR1023 locus on chromosome 10 in the male F2 progenies. 4. Salt-sensitive hypertensive gene is mapped to a region near D3Mgh12 locus on chromosome 3 in the female F2 progenies. [ABSTRACT FROM AUTHOR]