부산대학교 도서관

Pods of Caesalpinia ferrea, popularly used to treat inflammatory processes, were collected to obtain the polysaccharide-rich extract, presenting anti-inflammatory and antinociceptive effects in acute inflammation models. This study aimed to evaluate the anti-inflammatory, antinociceptive and healing activities of the polysaccharide-rich extract from Caesalpinia ferrea pods (PEp-Cf) in the rat model of cutaneous excisional wound. PEp-Cf (0.025–0.1%) or 0.9% NaCl was topically applied in the wounds at dorsal thoracic region (2×/day) during 21 days for measurement of clinical signs (hyperemia, inflammatory exudate, edema, nociception), wound size, histopathological/histomorphometric, oxidative/inflammatory markers and systemic toxicity. PEp-Cf at 0.1% reduced wound area and increased ulcer contraction [days 2 and 10 (21–78%)]. PEp-Cf reduced clinical signs [days 2 and 5 (2.2–2.8×)] and modulated the healing inflammatory phase via stimulation of epithelialization (days 10 and 14), and inhibition of polymorphonuclears [days 2 and 5 (71–74%)], protein leakage [days 2 and 5 (28–41%)], nitrate [days 2 and 5 (2.2–6×)] and malondialdehyde [days 2 and 5 (46–49%)]. PEp-Cf increased the number of blood vessels [days 5 and 7 (3.1–9.6×)], fibroblasts [days 5 and 7 (2.1–6.4×)] and collagen [days 5 to 14 (1.5–1.8×)]. In conclusion, the topical application of PEp-Cf at 0.1% accelerates the healing process of rat cutaneous wounds via modulation of the inflammatory and proliferative phases, being devoid of systemic alterations. [ABSTRACT FROM AUTHOR]