학술논문
Passerini Reaction to Access α‐Hydroxy Amides by Facile Decarbonylation/Decarboxylation of Oxalic Acid.
Document Type
Article
Source
Subject
*DECARBONYLATION
*OXALIC acid
*DECARBOXYLATION
*AMIDES
*MICROWAVE heating
*MICROWAVE chemistry
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*
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Language
ISSN
1434-193X
Abstract
α‐Hydroxy amides are an essential class of compounds found in natural products and bioactive molecules of drug candidates. Herein we report a facile and direct approach to these compounds through oxalic acid decarbonylation/decarboxylation during the Passerini three‐component reaction (P‐3CR) under solvent‐free conditions with microwave heating. This very convenient methodology provides the title compounds through a possible concerted intramolecular decarbonylation/decarboxylation from the α‐acyloxy amide intermediate. [ABSTRACT FROM AUTHOR]