학술논문
Earlier detection of gestational diabetes impacts on medication requirements, neonatal and maternal outcomes.
Document Type
Article
Author
Tirado‐Aguilar, Omar Alberto; Martinez‐Cruz, Nayeli; Arce‐Sanchez, Lidia; Borboa‐Olivares, Hector; Reyes‐Muñoz, Enrique; Espino‐y‐Sosa, Salvador; Villafan‐Bernal, Jose Rafael; Martinez‐Portilla, Raigam Jafet; Estrada‐Gutierrez, Guadalupe; Uribe‐Torres, Regina; Tirado Aguilar, Ricardo Daniel; Lopez‐Torres, Maria Fernanda; Ramos‐Mendoza, Cecilia; Camacho‐Martinez, Zaira Alexi; Aguilar‐Jaimes, Nelson Yesid; Torres‐Torres, Johnatan
Source
Subject
Language
ISSN
1462-8902
Abstract
Aim Materials and Methods Results Conclusion Gestational diabetes (GD) is a global health concern with significant implications for maternal and neonatal outcomes. This study investigates the association between early GD (eGD) diagnosis (<24 weeks), pharmacotherapy requirements and adverse neonatal outcomes.A cohort of 369 pregnant women underwent a 75‐g oral glucose tolerance test. Maternal variables, pharmacotherapy prescriptions and neonatal outcomes were analysed employing t‐tests, χ2 tests, and logistic regression. A p < .05 was considered significant.Early GD increased the odds of neonatal hypoglycaemia [odds ratio (OR): 18.57, p = .013] and respiratory distress syndrome (OR: 4.75, p = .034). Nutritional therapy prescription by an accredited nutritionist was the most common treatment in women diagnosed after 24 weeks, but those with eGD required more frequently specialized nutritional consulting + metformin to achieve glycaemic control (p = .027). eGD was associated with a higher requirement of nutritional therapy prescription + metformin (OR: 2.26, 95% confidence interval: 1.25‐4.09, p = .007) and with maternal hyperglycaemia during the post‐partum period at 2 h of the oral glucose tolerance test (OR: 1.03, 95% confidence interval: 1.02‐1.13, p = .024).Timely diagnosis and personalized treatment of GD are desirable because an earlier presentation is related to a higher risk of adverse neonatal and maternal outcomes. [ABSTRACT FROM AUTHOR]