학술논문

Nonleaching Antimicrobial Films Prepared from Surface-Modified Microfibrillated Cellulose.
Document Type
Article
Source
Biomacromolecules. Jul2007, Vol. 8 Issue 7, p2149-2155. 7p.
Subject
*LEACHING
*ANTI-infective agents
*CELLULOSE
*GRAM-negative bacteria
Language
ISSN
1525-7797
Abstract
We have prepared potentially permanent antimicrobial films based on surface-modified microfibrillated cellulose (MFC). MFC, obtained by disintegration of bleached softwood sulfite pulp in a homogenizer, was grafted with the quaternary ammonium compound octadecyldimethyl(3-trimethoxysilylpropyl)ammonium chloride (ODDMAC) by a simple adsorption-curing process. Films prepared from the ODDMAC-modified MFC were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) and tested for antibacterial activity against the Gram-positive bacterium Staphylococcus aureusand the Gram-negative bacteria Escherichia coliand Pseudomonas aeruginosa. The films showed substantial antibacterial capacity even at very low concentrations of antimicrobial agent immobilized on the surface. A zone of inhibition test demonstrated that no ODDMAC diffused into the surroundings, verifying that the films were indeed of the nonleaching type. [ABSTRACT FROM AUTHOR]