부산대학교 도서관

• A compartmental model was developed for studying the drug release. • The materials were porous and obtained with scCO 2 techniques. • Statistical results indicated that proper fits and goodness were obtained. • The model was able to predict the existence of lag phases. • Mass transfer coefficients of the different compartments were calculated. A global release model is proposed to study the drug release from porous materials for pharmaceutical applications. This model is defined by implementing a compartmental model where the release profile could be explained as the combination of mass transfer phenomena through three compartments as well as a desorption process or dissolution process from the support. This model was validated with five different systems produced with supercritical CO 2 (aerogels, membranes, and fibers), showing different release processes. Numerical results indicate that this compartmental approach can be useful to determine adsorption and desorption constants as well as mass transfer resistances within the material. Likewise, this model can predict lag phases and imbibition phenomena. Therefore, the development of compartmental models can be an alternative to traditional models to successfully predict the drug profile of porous materials, achieving a complete understanding of the involved phenomena regardless of the material characteristics. [Display omitted] [ABSTRACT FROM AUTHOR]