학술논문
Hantavirus Gn and Gc Glycoproteins Self-Assemble into Virus-Like Particles.
Document Type
Article
Author
Source
Subject
*HANTAVIRUSES
*GLYCOPROTEINS
*VIRUS-like particles
*NUCLEOPROTEINS
*VIRUSES
*
*
*
*
Language
ISSN
0022-538X
Abstract
How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were released to cell supernatants. The viral nucleoprotein was not required for particle formation. Further, a Gc endodomain deletion mutant did not abrogate VLP formation. The VLPs were pleomorphic, exposed protrusions and reacted with patient sera. [ABSTRACT FROM AUTHOR]