학술논문
Treatment with rIFN-γ has no effect on cardiac allograft rejection.
Document Type
Article
Source
Subject
*HOMOGRAFTS
*CARDIAC surgery
*GLYCOPROTEINS
*ANTINEOPLASTIC agents
*MORTALITY
*HEART transplantation
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Language
ISSN
0019-2805
Abstract
The effect of recombinant rat interferon-gamma (rRIFN-γ) on allograft rejection was studied in two rat heart transplantation models. Recipients were treated with rRIFN-γ by intraperitoneal or intravenous injection, either by bolus or continuous infusion. Treatment was started after transplantation and continued during a period ranging from 4 to 10 days; dosages varied from 25 × 10² U/kg/day to 3 × 106 U/kg/day. Controls were infused with PBS. Treatment with rRIFN-γ had no effect on allograft survival, irrespective of the route of administration, the dosage used or the duration of treatment:' Higher dosages of rRIFN-γ induced serious morbidity and mortality. In conclusion, systemic treatment of cardiac allograft recipients with rRIFN-γ has no effect on graft rejection and is associated with serious toxicity and mortality when high dosages are used. [ABSTRACT FROM AUTHOR]