학술논문
Bcl-2 inhibits p53 nuclear import following DNA damage.
Document Type
Article
Author
Source
Subject
*MYC proteins
*DNA
*CELL physiology
*MEDICAL genetics
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Language
ISSN
0950-9232
Abstract
Bcl-2 is an integral membrane oncoprotein that localizes to membranes of the mitochondria, endoplasmic reticulum, and nuclear envelope. Bcl-2 is a member of a family of cell death regulators and functions to inhibit apoptosis. Using confocal microscopy and immunoblotting we show that the ability of bcl-2 to suppress cell death following genotoxic damage can be a consequence of inhibiting nuclear import of induced wild-type p53 protein. Our data suggests that the ability of bcl-2 to modulate trafficking events is not cell type specific. These data support a `gatekeeper' mechanism for cell death suppression by bcl-2. [ABSTRACT FROM AUTHOR]