부산대학교 도서관

Simple Summary: Hyperthermia (HT) is a commonly used technique applied as an effective sensitizer during cancer therapy. However, the localized heating of the tumor due to supraphysiological temperature may cause serious side effects towards normal tissues. Thus, new methods are needed to improve the precision of HT. Nanotechnology has allowed for the development of many promising tools to revolutionize traditional thermotherapy. Here, we showed that magnetic nanoparticles (MNPs) following activation by altered magnetic field not only destroy tumor cells but also cause increased blood flow to and oxygenation of cancer tissue. Moreover, we present the current state of knowledge regarding the combination of MNPs-based hyperthermia with traditional and innovative cancer therapies as well perspectives on its implementation within clinics. Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39–45 °C) to inhibit tumor growth. However, controlling heat towards tumors and not normal tissues is challenging. Therefore, nanoparticles (NPs) are used in HT to apply heat only to tumor tissues to induce DNA damage and the expression of heat shock proteins, which eventually result in apoptosis. The aim of this review article is to summarize recent advancements in HT with the use of magnetic NPs to locally increase temperature and promote cell death. In addition, the recent development of nanocarriers as NP-based drug delivery systems is discussed. Finally, the efficacy of HT combined with chemotherapy, radiotherapy, gene therapy, photothermal therapy, and immunotherapy is explored. [ABSTRACT FROM AUTHOR]