학술논문
The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia.
Document Type
Article
Author
Source
Subject
*CHROMOSOME duplication
*ACUTE myeloid leukemia
*BONE marrow diseases
*GENE expression
*GENOMES
*GENETICS
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Language
ISSN
0887-6924
Abstract
The article explores the partial tandem duplication of the MLL gene (MLL-PTD) among adults aged 60 years old and above who have de novo cytogenitically normal acute myeloid leukemia (CN-AML). It examines blood or bone marrow of such patients who were treated on Cancer and Leukemia Group B. Also, it conducts genome-wide gene and microRNA-expression profiling, and assays to observe other molecular aberrations with prognostic significance in CN-AML.