학술논문
Liver X Receptor-dependent Repression of Matrix Metalloproteinase-9 Expression in Macrophages.
Document Type
Article
Author
Source
Subject
*METALLOPROTEINASES
*NUCLEAR receptors (Biochemistry)
*MACROPHAGES
*LIGANDS (Biochemistry)
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Language
ISSN
0021-9258
Abstract
Demonstrates that ligand activation of the nuclear receptors LXRα and LXRβ inhibits the expression of matrix metalloproteinase-9 (MMP-9) in macrophages. Accomplishment of LXR-dependent repression of MMP-9 through inhibition of the nuclear factor-κΒ pathway rather than direct binding of LXR/RXR heterodimers to the MMP-9 promoter.