학술논문

Missorting of plasma miRNAs in aging and Alzheimer's disease.
Document Type
Article
Source
Journal of Neurochemistry. 4/15/2023, Vol. 165 Issue 2, p149-161. 13p.
Subject
*ALZHEIMER'S disease
*DISEASE risk factors
*MICRORNA
*AGING
*EXTRACELLULAR vesicles
Language
ISSN
0022-3042
Abstract
The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient. [ABSTRACT FROM AUTHOR]