학술논문

Coexistence of Neurofibromatosis Type 1 and Male Breast Cancer.
Document Type
Article
Source
Archives of Iranian Medicine (AIM). Nov2021, Vol. 24 Issue 11, p852-855. 4p.
Subject
*EPIDERMAL growth factor receptors
*ESTROGEN
*MALE breast cancer
*NEUROFIBROMATOSIS 1
*COMORBIDITY
*PROGESTERONE receptors
Language
ISSN
1029-2977
Abstract
Breast cancer is one of the rarest types of cancer in men. Its incidence increases with age, as in women. Neurofibromatosis type 1 is an autosomal dominant genetic disease that predisposes to many cancer types. Neurofibromatosis and breast cancer have been more frequently distinguished and better studied in women. Characteristically, estrogen, progesterone receptors, negative, and overexpression of human epidermal growth factor receptor 2 (HER2) are detected in patients with female neurofibromatosis breast cancers. In cases reported so far, estrogen and progesterone receptors have been evaluated as positive and HER2 negative in male patients. With the high possibility of breast cancer development in female patients with neurofibromatosis at an earlier age, prompt and careful evaluation is required in terms of both examination and radiological imaging. Unfortunately, there are no thorough recommendations for breast cancer follow-up in male patients with neurofibromatosis. Here, we present a breast cancer, which is an uncommon type of cancer in male neurofibromatosis. [ABSTRACT FROM AUTHOR]