학술논문
Study of Serum Zinc Levels in Newly Detected type 2 Diabetes Mellitus and it's Correlation with HbA1c.
Document Type
Article
Author
Source
Subject
*TYPE 2 diabetes
*GLYCOSYLATED hemoglobin
*ZINC
*GLYCEMIC control
*DIABETES complications
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Language
ISSN
0975-3583
Abstract
Background: Hyperglycemia is considered as a primary culprit of diabetic complications and is associated with increased metabolic processes and oxidative stress. Both micro vascular and macro vascular complications in diabetes are related to oxidative stress and zinc has antioxidant properties delaying the diabetic complications Objective: To study the levels of serum zinc and HbA1c in newly detected type 2 diabetes mellitus, To correlate between serum zinc levels and HbA1c in predicting the importance of zinc levels for glycemic control. Methods: This Cross sectional study was conducted among patients visiting the opd/or admitted in Department of General Medicine, KR Hospital, MMCRI, Mysore, Mysore. Study period was one and a half year from February 2021 to June 2022. Results: Out of the 105 patients mean age was 49.57yrs with a range of 32 yrs to 70 yrs. Out of 105 patients 59 were females with 46 being males. Approximately 50% of the females were in the age group of 41 to 50 yrs and 18(39.1%) males were in the age range of 51 to 60 yr. Overall mean FBS was 146.99 ± 9.761, mean PPBS was 224.24 ± 15.724, mean RBS was 170.37 ± 14.241, mean HbA1C was 9.34 ± 1.48 and mean Zinc levels was 102.01 ± 75.56. In females, Mean FBS was 146.31 ± 8.518, mean PPBS was 225.12 ± 15.456, mean RBS was 170.59 ± 15.112, mean HbA1C was 9.4 ± 1.5 and mean Zinc levels was 114.6 ± 88. In males, Mean FBS was 147.87 ± 11.192, mean PPBS was 223.11 ± 16.161, mean RBS was 170.09 ± 13.197, mean HbA1C was 9.2 ± 1.5 and mean Zinc levels was 85.8 ± 52.3. Mean Zinc levels were higher for subjects having HbA1c between 8.1 to 10- 109.47 ± 70.90 followed by subjects having HbA1C > 10 - 95.78 ± 103.59. Conclusion: Very weak, positive and non-significant correlation was seen between PPBS and Zinc (r = 0.076, p=0.440), RBS and Zinc (r=0.089, p=0.367). Hence no significant relation was drawn from the study and in the present study levels of serum zinc didn’t correlate with poor control of diabetes mellitus in terms of HbA1c. [ABSTRACT FROM AUTHOR]