학술논문
Obesity and lung cancer - is programmed death ligand-1 (PD-1L) expression a connection?
Document Type
Article
Author
Source
Subject
*LUNG cancer
*BODY mass index
*OVERWEIGHT women
*GAUSSIAN distribution
*OBESITY
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Language
ISSN
1734-1922
Abstract
Introduction: In this retrospective study, the authors evaluated whether obesity-induced immunomodulation impacts the expression of programmed death ligand-1 (PD-1L) in lung cancer cells. Methods: A retrospective cross-sectional study was performed. The study included 67 patients. The data did not have a normal distribution. Results: For women, using ANOVA test (p = 0.050) with post-hoc analysis, a statistically significant difference in expression was found between women with overweight and women with normal weight (p = 0.040). Conclusions: Apart from the above, the authors did not find any statistically significant correlation between PD-1L expression on lung cancer cells and body mass index, either in the whole group or in histological subgroups. [ABSTRACT FROM AUTHOR]