학술논문
Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression.
Document Type
Article
Source
Subject
*ATHEROSCLEROSIS
*AGE factors in disease
*TYPE 2 diabetes
*MESENCHYMAL stem cells
*ADIPOSE tissues
*T cells
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Language
ISSN
1757-6512
Abstract
To this end human MSCs were isolated from adipose tissue and the MSC:CD4+ T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies. [ABSTRACT FROM AUTHOR]