학술논문
Numerical evaluation of spray position for improved nasal drug delivery.
Document Type
Article
Author
Basu, Saikat; Holbrook, Landon T.; Kudlaty, Kathryn; Fasanmade, Olulade; Wu, Jihong; Burke, Alyssa; Langworthy, Benjamin W.; Farzal, Zainab; Mamdani, Mohammed; Bennett, William D.; Fine, Jason P.; Senior, Brent A.; Zanation, Adam M.; Ebert, Charles S.; Kimple, Adam J.; Thorp, Brian D.; Frank-Ito, Dennis O.; Garcia, Guilherme J. M.; Kimbell, Julia S.
Source
Subject
*INTRANASAL medication
*DRUG delivery systems
*DIAGNOSTIC imaging
*COMPUTATIONAL fluid dynamics
*THREE-dimensional printing
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Language
ISSN
2045-2322
Abstract
Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]