학술논문
Synthesis and Cytotoxic Studies of Pyrrole and Pyrrolidine Derivatives in Human Tumor Cell Lines.
Document Type
Article
Author
Source
Subject
*PYRROLE derivatives
*CELL lines
*CHRONIC myeloid leukemia
*HIERARCHICAL clustering (Cluster analysis)
*CLUSTER analysis (Statistics)
*HETEROCYCLIC compounds
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Language
ISSN
2365-6549
Abstract
Heterocyclic compounds such as pyrrole and pyrrolidine derivatives have a broad spectrum of biological activity, being widely used as pharmacophore to design novel bioactive compounds. In this work, sixteen pyrrole and pyrrolidine derivatives were synthesized and evaluated for their growth inhibitory activity on two human cancer cells lines: breast cancer MDA‐MB‐231 and chronic myelogenous leukemia (K562). Eight compounds showed activity against at least one tumor cell line (IC50=49.15–195.9 μM). The compounds were tested in non‐cancerous human lung fibroblasts WI‐26VA4 to evaluate their selectivity index. In addition, Hierarchical Cluster Analysis (HCA) studies were carried out in attempt to establish a structure‐activity relationship. [ABSTRACT FROM AUTHOR]