학술논문
The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma.
Document Type
Article
Source
Subject
*CELLULAR aging
*SQUAMOUS cell carcinoma
*NEOPLASTIC cell transformation
*ONCOGENES
*CANCER genes
*
*
*
*
Language
ISSN
1553-7390
Abstract
The article offers information on the importance of cellular senescence as a tumor-suppressing mechanismin response to numerous cellular threats including telomere loss, oxidative stress, and oncogene activation. The important role of senescence in suppression of tumorigenesis in vivo is mentioned. Other topics tackled include Modulating FXR1 Activity to Treat HNSCC and Facioscapulohumeral Muscular Dystrophy and Bypass of Cellular Senescence by FXR1 and Transformation.