부산대학교 도서관

Background: Acute right ventricular (RV) failure is common in patients hospitalized with COVID‐19. Compared to the conventional echocardiographic parameters, right ventricular longitudinal strain (RVLS) is more sensitive and accurate for the diagnosis of RV systolic dysfunction. Objective: Our purpose was to investigate the sustained RV dysfunction echo‐quantified by RVLS in patients recovered from severe COVID‐19. Furthermore, we aimed to assess whether disseminated intravascular coagulation (DIC) has a key role to predict the impaired RV strain. Methods: Of 198 consecutive COVID‐19 patients hospitalized from March 1, 2020, to April 15, 2020, 45 selected patients who survived from severe COVID‐19 were enrolled in the study and referred to our echo‐lab for transthoracic echocardiography 6‐months after discharge. RVLS was calculated as the mean of the strain values of RV free wall. DIC was defined with a validated scoring system: DIC score equal to or more than 5 is compatible with overt‐DIC. Categories of acute respiratory distress syndrome (ARDS) were defined based on PaO2/FiO2 ratio. Results: A total 26 of 45 patients showed impaired RVLS at 6‐months' follow‐up. DIC score was significantly higher in patients with worse RVLS than in those with better RVLS (4.8 ±.5 vs. 3.6 ±.6, p =.03). Stages of ARDS did not modulate this relationship. Finally, overt‐DIC results the only independent predictor of sustained RV dysfunction (OR 1.233, 95% CI 1.041–1.934, p =.043). Conclusions: Sustained RV impairment frequently occurs in patients recovered from severe COVID‐19. DIC plays a key role, resulting in an independent predictor of sustained RV dysfunction. [ABSTRACT FROM AUTHOR]