학술논문
Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma.
Document Type
Article
Author
Mirian, Christian; Grell, Kathrine; Juratli, Tareq A.; Sahm, Felix; Spiegl‐Kreinecker, Sabine; Peyre, Matthieu; Biczok, Annamaria; Tonn, Jörg‐Christian; Goutagny, Stéphane; Bertero, Luca; Maier, Andrea Daniela; Jensen, Lasse Rehné; Schackert, Gabriele; Broholm, Helle; Scheie, David; Cahill, Daniel P.; Brastianos, Priscilla K.; Skjøth‐Rasmussen, Jane; Fugleholm, Kåre; Ziebell, Morten
Source
Subject
*PROPORTIONAL hazards models
*MENINGIOMA
*
Language
ISSN
0305-1846
Abstract
I TERT i promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. I TERT i p-mut affected 45 out of the 410 patients (12.3%), comprising 12 C250T and 33 C228T (73.3%) I TERT i promoter mutations, whereas the remaining 365 patients had the I TERT i promoter wild-type counterpart ( I TERT i p-wt). We recently described an association between patients with a I Telomerase reverse transcriptase i ( I TERT i ) gene alterations and a poor prognosis irrespective of the WHO grade in a meta-analysis of individual patient data encompassing all hitherto published meningioma patients with such alterations [3]. [Extracted from the article]