부산대학교 도서관

This article explores the challenges of translating preclinical research on cardiovascular disease (CVD) to the clinical setting. It focuses on the limitations of animal models, specifically pig models, in accurately representing human atherosclerotic ischemic heart disease. The authors highlight a recent study that characterizes the vascular function of Ossabaw minipigs, a pig model with a genetic predisposition to develop metabolic syndrome and coronary atherosclerosis. The study suggests that pre-MetS Ossabaw pigs could serve as a relevant animal model for studying CVD. The article emphasizes the importance of using a preclinical pig model to study cardiovascular disease and evaluate prevention interventions, despite the higher cost. The authors stress the need for rigorous and reproducible preclinical testing to improve translational research in this field. [Extracted from the article]