학술논문
Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
Document Type
Article
Author
Source
Subject
*LEUCINE
*CELL growth
*PROGENITOR cells
*PHOSPHORYLATION
*RIBOSOMAL proteins
*MYELODYSPLASTIC syndromes
*MTOR protein
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Language
ISSN
0887-6924
Abstract
The article presents a study which examines the potential role of L-leucine in cell growth and human erythroid progenitor cells. It analyzes the effects of L-leucine on the phosphorylation levels of ribosomal protein gene RPS14-deficient erythroblasts in patients with del(5q) myelodysplastic syndromes (MDS) and mTORC1 signaling. It suggests that L-leucine treatment may result to the improvement of erythroid defect in patients with del(5q) MDS.