부산대학교 도서관

Keywords: Basophils; chronic spontaneous urticarial; microRNA; omalizumab; response biomarker EN Basophils chronic spontaneous urticarial microRNA omalizumab response biomarker 1648 1652 5 11/30/21 20211201 NES 211201 Key Messages In chronic spontaneous urticaria, a unique basophil microRNA signature associates with complete response to omalizumab. Since microRNA expression levels correlate with clinical response, corroboration of this basophil microRNA signature in a second cohort of CSU patients is needed for their validation as biomarkers. Commercial microRNA panels have been developed to identify the origin or classification of cancers.9 The basophil microRNA expression profiles identified in our study (ie miR-4664-3p, miR-1200, and miR-1236-3p) could serve as a diagnostic panel to guide physicians in selecting CSU patients for omalizumab intervention. [Extracted from the article]