학술논문
MRSamePopTest: introducing a simple falsification test for the two-sample mendelian randomisation 'same population' assumption.
Document Type
Article
Author
Source
Subject
*FALSIFICATION
*CAUSAL inference
*SENSITIVITY analysis
*HOMOGENEITY
*
*
*
Language
ISSN
1756-0500
Abstract
Key message: • Two-sample Mendelian randomisation (2SMR) can be used to estimate the lifetime effect of a modifiable exposure on an outcome of interest. • 2SMR point estimates are not interpretable if the exposure and outcome GWASs do not come from homogeneous populations, so called 'same population' assumption. However, this assumption is often not validated in applied studies. • We propose and validate a novel sensitivity analysis for this assumption, which checks if SNP effects for the same trait are homogeneous across the two populations. [ABSTRACT FROM AUTHOR]