부산대학교 도서관

Background: Autoimmune manifestations can occur in the context of HIV immune reconstitution inflammatory syndrome (IRIS). Previous studies have shown that GM2 is overexpressed on HIV‐1 infected T lymphocytes. Case presentation: A 71‐year‐old patient diagnosed with HIV‐1 infection developed neurological symptoms congruent with meningoradiculitis 1 month after initiation of antiretroviral therapy. Concurrent syphilitic seroconversion raised the hypothesis of neurosyphilis, which was later infirmed. Serum antiganglioside immunoglobulin M antibodies were highly positive. Treatment with intravenous immunoglobulins was effective. Conclusion: We postulate that meningoradiculitis in this patient was a consequence of anti‐GM2 antibodies produced as part of an anti‐HIV‐1 immune response, and that this case falls within the scope of autoimmune manifestations linked to HIV IRIS. [ABSTRACT FROM AUTHOR]