학술논문
Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway.
Document Type
Article
Author
Source
Subject
*PROTEIN kinases
*STATISTICAL significance
*MEDICINAL plants
*CELL culture
*ANTI-inflammatory agents
*ANIMAL experimentation
*WESTERN immunoblotting
*ONE-way analysis of variance
*ANTIOXIDANTS
*ANTINEOPLASTIC agents
*TYPE 2 diabetes
*CELLULAR signal transduction
*RESEARCH funding
*PLANT extracts
*DATA analysis software
*INSULIN resistance
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Language
ISSN
1028-6020
Abstract
Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO2 cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury. [ABSTRACT FROM AUTHOR]