학술논문
Oral contrast enhances the resolution of in-life NIS reporter gene imaging.
Document Type
Article
Author
Source
Subject
*SODIUM iodide
*CANCER cells
*CANCER genetics
*CANCER tomography
*RADIOACTIVE tracers
*SIGNAL detection
*ANIMAL models in research
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Language
ISSN
0929-1903
Abstract
Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs. [ABSTRACT FROM AUTHOR]