학술논문
Sequential Seyferth-Gilbert/CuAAC Reactions: Application to the One-Pot Synthesis of Triazoles from Aldehydes.
Document Type
Article
Source
Subject
*TRIAZOLES synthesis
*ALDEHYDES
*RING formation (Chemistry)
*ALKYNE synthesis
*BORONIC acids
*BIOCONJUGATES
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Language
ISSN
0936-5214
Abstract
A reliable and operationally simple one-pot reaction for a one-carbon homologation of various aldehydes followed by a Cu-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in good to excellent yields from a variety of readily available aldehydes without the need for isolation of the alkyne intermediates. The reaction has a broad scope, allows the formation of new bioconjugates and is applied for the synthesis of new boronic acid based fluorescent sensors. [ABSTRACT FROM AUTHOR]