학술논문
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Document Type
Article
Author
Source
Subject
*VAGINAL cancer
*CANCER treatment
*RADIOEMBOLIZATION
*RADIOTHERAPY
*ONCOLOGY research
*TOXICITY testing
*HEALTH risk assessment
*CANCER relapse
*ENDOMETRIAL cancer
*ENDOMETRIAL surgery
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Language
ISSN
0140-6736
Abstract
The article presents a study that compares the effectiveness of vaginal brachytherapy (VBT) and pelvic external beam radiotherapy (EBRT) in the prevention of vaginal recurrence after intermediate-risk endometrial carcinoma surgery. It states that the study is an open-label, non-inferiority, and randomized trial that was undertaken in 19 Dutch radiation oncology centers in which 427 patients with stage I or IIA endometrial carcinoma went through EBRT and VBT. The results showed that the rates of acute grade 1-2 gastrointestinal toxicity is lower in VBT group than the EBRT group. It concludes that VBT offers effective vaginal control with less gastrointestinal toxic effects.