학술논문
Postoperative glucocorticoids in patients with acute type A aortic dissection (GLAD): study protocol for a prospective, single-center, randomized controlled trial.
Document Type
Article
Author
Source
Subject
*GLUCOCORTICOIDS
*METHYLPREDNISOLONE
*INTRAVENOUS therapy
*AORTIC aneurysms
*MULTIPLE organ failure
*IMPLANTABLE cardioverter-defibrillators
*TREATMENT effectiveness
*RANDOMIZED controlled trials
*COMPARATIVE studies
*POSTOPERATIVE period
*DRUG therapy
*RESEARCH funding
*BLIND experiment
*STATISTICAL sampling
*AORTIC dissection
*LONGITUDINAL method
*DISEASE complications
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Language
ISSN
1471-2253
Abstract
Background: Patients receiving surgical treatment of acute type A Aortic Dissection (aTAAD) are common to suffer organ dysfunction in the intensive care unit due to overwhelming inflammation. Previous studies have revealed that glucocorticoids may reduce complications in certain patient groups, but evidence between postoperative glucocorticoids administration and improvement in organ dysfunction after aTAAD surgery are lacking. Methods: This study will be an investigator-initiated, prospective, single-blind, randomized, single-center study. Subjects with confirmed diagnosis of aTAAD undergoing surgical treatment will be enrolled and 1:1 randomly assigned to receive either glucocorticoids or normal treatment. All patients in the glucocorticoids group will be given methylprednisolone intravenously for 3 days after enrollment. The primary endpoint will be the amplitude of variation of Sequential Organ Failure Assessment score on post-operative day 4 compared to baseline. Discussion: The trial will explore the rationale for postoperative application of glucocorticoids in patients after aTAAD surgery. Trial registration: This study has been registered on ClinicalTrials.gov (NCT04734418). [ABSTRACT FROM AUTHOR]