부산대학교 도서관

Among disease vectors, Aedes aegypti (L.) (Diptera: Culicidae) is one of the most insidious species in the world. The disease burden created by this species has dramatically increased in the past 50 years, and during this time countries have relied on pesticides for control and prevention of viruses borne by Ae. aegypti. The small number of available insecticides with different modes of action had led to increases in insecticide resistance, thus, strategies, like the "Incompatible Insect Technique" using Wolbachia's cytoplasmic incompatibility are desirable. We evaluated the effect of releases of Wolbachia infected Ae. aegypti males on populations of wild Ae. aegypti in the metropolitan area of Houston, TX. Releases were conducted by the company MosquitoMate, Inc. To estimate mosquito population reduction, we used a mosquito abundance Bayesian hierarchical estimator that accounted for inefficient trapping. MosquitoMate previously reported a reduction of 78% for an intervention conducted in Miami, FL. In this experiment we found a reduction of 93% with 95% credibility intervals of 86% and 96% after six weeks of continual releases. A similar result was reported by Verily Life Sciences, 96% [94%, 97%], in releases made in Fresno, CA. Author summary: Aedes aegypti is one of the most important mosquito species because females can potentially carry pathogens that cause disease. These diseases have a tremendous impact worldwide making this species an important target of control. We evaluated a mosquito control strategy independently of the company that developed the method while the company tested it in Harris County, TX. The strategy relies on a bacterium (Wolbachia sp) that causes changes in the sperm of infected males, preventing uninfected female mosquitoes from producing viable eggs (phenomenon known as cytoplasmic incompatibility). Wolbachia-infected males are released in large numbers (inundative releases) to outcompete wild-type Wolbachia-free males and reduce the population of existing Ae. aegypti mosquitoes. We observed a sustained reductions > 90% in the number of females very likely because of the intervention conducted in Harris County, TX. The results we observed were very similar to observations made by others in Miami, FL and in Fresno, CA. However, more experiments (following randomized cluster designs) should be performed to increase the statistical power while controlling for environmental factors that could contribute to fluctuations in mosquito populations and trapping variations. [ABSTRACT FROM AUTHOR]