학술논문
Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.
Document Type
Journal Article
Author
Lokugamage, Kumari; Kariwa, Hiroaki; Hayasaka, Daisuke; Bai Zhong Cui; Iwasaki, Takuya; Lokugamage, Nandadeva; Ivanov, Leonid I.; Volkov, Vladimir I.; Demenev, Vladimir A.; Slonova, Raisa; Kompanets, Galina; Kushnaryova, Tatyana; Kurata, Takeshi; Maeda, Kenji; Araki, Koichi; Mizutani, Tetsuya; Yoshimatsu, Komiko; Kurata, Jiro; Cui, Bai Zhong; Yoshimatsu, Kumiko
Source
Subject
*HANTAVIRUS diseases
*MICROTUS
*RODENTS as carriers of disease
*ANIMAL experimentation
*CARRIER state (Communicable diseases)
*COMPARATIVE studies
*DNA
*DOCUMENTATION
*BIOLOGICAL evolution
*GENETICS
*HANTAVIRUSES
*RESEARCH methodology
*MEDICAL cooperation
*MICE
*NUCLEIC acid hybridization
*NUCLEOTIDES
*POLYMERASE chain reaction
*RESEARCH
*RNA
*VIRAL antibodies
*EVALUATION research
*REVERSE transcriptase polymerase chain reaction
*INFECTIOUS disease transmission
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Language
ISSN
1080-6040
Abstract
In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia. [ABSTRACT FROM AUTHOR]