부산대학교 도서관

This letter, published in the Journal of Translational Medicine, discusses the role of senescent cancer-associated fibroblasts (CAFs) in tumor immunity in lung adenocarcinoma. The authors found that senescent cells, particularly senescent CAFs, were increased in lung adenocarcinoma tissues compared to normal adjacent tissues. They also discovered that senescent CAFs facilitated the recruitment of neutrophils, which suppressed T cell infiltration and tumor immunity. The study suggests that targeting senescent CAFs may be a potential therapeutic strategy for improving the efficacy of immunotherapy in lung adenocarcinoma. [Extracted from the article]