학술논문
Managing the significant drug‐drug interaction between tacrolimus and letermovir in solid organ transplant recipients.
Document Type
Article
Author
Source
Subject
*TACROLIMUS
*TRANSPLANTATION of organs, tissues, etc.
*AIDS-related opportunistic infections
*
*
Language
ISSN
0902-0063
Abstract
GLO:FQT/01mar21:ctr14213-fig-0001.jpg PHOTO (COLOR): 1 (A) Total daily tacrolimus dose (mg/kg) and (B) dose-corrected trough concentration (ng/ml/mg) for patients with and without letermovir gl To our knowledge, this is the first study assessing the magnitude of tacrolimus dose-requirement changes among SOT recipients starting letermovir therapy. Managing the significant drug-drug interaction between tacrolimus and letermovir in solid organ transplant recipients These results suggest that an approximate tacrolimus dose reduction of 30% may be warranted when initiating letermovir to achieve a comparable dose-corrected trough concentration. [Extracted from the article]