학술논문
Oral booster vaccine antigen—Expression of full‐length native SARS‐CoV‐2 spike protein in lettuce chloroplasts.
Document Type
Article
Author
Source
Subject
*BOOSTER vaccines
*GENE expression
*ORAL vaccines
*CHLOROPLASTS
*SARS-CoV-2
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Language
ISSN
1467-7644
Abstract
The CTB-Spike quantified by comparing CTB standard using 55.5, 38.6, 23.1, 12.6, and 6.8 ng in total protein loaded (120, 100, 50, 25 and 12.5 ng), respectively resulting in 46.2%, 38.5%, 46.1%, 50.5%, 54.4% of CTB-Spike in total leaf protein. Keywords: COVID-19; edible plant; plant vaccine; SARS-CoV-2 EN COVID-19 edible plant plant vaccine SARS-CoV-2 887 889 3 04/19/23 20230501 NES 230501 Current vaccines continue to save lives during the pandemic but do not prevent virus transmission. Indeed, this is the first engineered therapeutic protein approved by FDA free of protein purification or cold chain, and clinical trials are in progress to evaluate SARS-CoV-2 infection and transmission (Daniell I et al i ., [2]). Therefore, one approach recently developed involved debulking SARS-CoV-2 or other oral viruses in saliva using virus-trap proteins via chewing gums to minimize self-infection and transmission (Daniell I et al i ., [1],[2]). [Extracted from the article]