학술논문
Targeting liver X receptors in cancer therapeutics.
Document Type
Article
Author
Source
Subject
*NUCLEAR receptors (Biochemistry)
*TRANSCRIPTION factors
*LIGANDS (Biochemistry)
*CANCER treatment
*GLUCOSE metabolism
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Language
ISSN
1474-175X
Abstract
Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses. There is now accumulating evidence to support the involvement of LXRs in a variety of malignancies and the potential efficacy of their ligands in these diseases. This Review summarizes the discovery and characterization of LXRs and their ligands, their effects and mechanisms in preclinical cancer models, and the future directions of basic and translational LXR research in cancer therapeutics. [ABSTRACT FROM AUTHOR]