학술논문
An oxaliplatin(iv) prodrug-based supramolecular self-delivery nanocarrier for targeted colorectal cancer treatment.
Document Type
Article
Source
Subject
*SUPRAMOLECULAR chemistry
*CYCLODEXTRINS
*CANCER treatment
*ALTERNATIVE treatment for cancer
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Language
ISSN
1359-7345
Abstract
A redox-responsive supramolecular nanocarrier was constructed from the self-assembly of spermine modified cyclodextrin and oxaliplatin prodrug. The nanocarrier could preferentially accumulate in polyamine transporter over-expressing HCT116 cells, releasing drugs under a reducing intracellular environment to maximize anticancer treatment. [ABSTRACT FROM AUTHOR]