학술논문
From a Sequential to a Concurrent Reaction in Aqueous Medium: Ruthenium-Catalyzed Allylic Alcohol Isomerization and Asymmetric Bioreduction.
Document Type
Article
Author
Source
Subject
*RUTHENIUM catalysts
*OXIDATION-reduction reaction
*ALLYL alcohol
*KETONES
*ENANTIOSELECTIVE catalysis
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Language
ISSN
1433-7851
Abstract
The ruthenium-catalyzed redox isomerization of allylic alcohols was successfully coupled with the enantioselective enzymatic ketone reduction (mediated by KREDs) in a concurrent process in aqueous medium. The overall transformation, formally the asymmetric reduction of allylic alcohols, took place with excellent conversions and enantioselectivities, under mild reaction conditions, employing commercially and readily available catalytic systems, and without external coenzymes or cofactors. Optimization resulted in a multistep approach and a genuine cascade reaction where the metal catalyst and biocatalyst coexist from the beginning. [ABSTRACT FROM AUTHOR]