학술논문
Modulation of Peripheral B Cell Tolerance by CD72 in a Murine Model.
Document Type
Article
Author
Source
Subject
*B cells
*CELL receptors
*SYSTEMIC lupus erythematosus
*CONNECTIVE tissue diseases
*MULTIPLE sclerosis
*AUTOIMMUNE diseases
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Language
ISSN
0004-3591
Abstract
The article presents a study which elucidates the role of CD72 in the modulation of B cell receptor (BCR)-mediated tolerogenic signaling and peripheral B cell tolerance through a murine model. The study concludes that CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance. Moreover, altered CD72 expression may play a dominant role in the pathogenesis of several autoimmune diseases, including systematic lupus erythematosus and multiple sclerosis.