학술논문

Immune Checkpoint Inhibitor Therapy: Key principles when educating patients.
Document Type
Article
Author
Source
Clinical Journal of Oncology Nursing. Jun2019, Vol. 23 Issue 3, p271-280. 10p. 1 Diagram, 2 Charts.
Subject
*PREVENTION of drug side effects
*CAREGIVER education
*ANTIGENS
*CANCER patient medical care
*CELL physiology
*CELLULAR signal transduction
*DRUG side effects
*HEALTH care teams
*IMMUNOLOGICAL adjuvants
*IMMUNOTHERAPY
*INTEGRATED health care delivery
*PATIENT education
*TUMORS
*TEACHING methods
*CONTINUING education units
*EARLY medical intervention
*EARLY diagnosis
*PHARMACODYNAMICS
*THERAPEUTICS
Language
ISSN
1092-1095
Abstract
BACKGROUND: Immune checkpoint inhibitor (ICI) therapy is a fast-developing field within the spectrum of cancer care. ICIs are associated with distinctive immune-related adverse events (irAEs), reflecting their unique mechanisms of action. OBJECTIVES: Effective management of irAEs requires early recognition and prompt reporting of their signs and symptoms; appropriate patient education is critical to maximizing this opportunity. METHODS: A comprehensive literature search was conducted in the public domain concerning awareness, assessment, and management of irAEs associated with ICIs. FINDINGS: Educational resources should provide timely, consistent, and personalized information, using a variety of teaching strategies that consider individual patient needs. Patient education should be developed with interprofessional team input and regularly reviewed in response to emerging guidance. Key messages include timing of therapeutic response and corresponding irAEs, early identification of irAEs, and the unique ability of ICIs to influence immune responses after treatment discontinuation. [ABSTRACT FROM AUTHOR]