학술논문
The AGE–RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease.
Document Type
Article
Author
Source
Subject
*KIDNEY diseases
*CARDIOVASCULAR diseases risk factors
*MORTALITY
*PATHOLOGICAL physiology
*ADVANCED glycation end-products
*HISTOLOGY
*PATIENTS
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Language
ISSN
0188-4409
Abstract
Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-products (AGE)–receptor for AGE (RAGE) pathway is likely a major contributor in patients with CKD. This review describes briefly some of the components of this pathway, highlighting especially differences between circulating AGE and tissue AGE and how activation of the AGE–RAGE pathway may promote CVD in CKD. [ABSTRACT FROM AUTHOR]